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Phamalene is for cutaneous use only. If the medication is applied excessively, no more rapid or better results will be
obtained and marked redness, scaling, or skin discomfort may occur.
The acute oral toxicity of Adapalene 0.1 % in mice and rats is greater than 10 ml/kg. Chronic ingestion of the drug may lead to the same side effects as those associated with excessive oral intake of vitamin A.
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