Ferriprox Drug Interactions

FC tab: Interactions between deferiprone and other medicinal products have not been reported. However, since deferiprone binds to metallic cations, the potential exists for interactions between deferiprone and trivalent cation-dependent medicinal products eg, aluminum-based antacids. Therefore, it is not recommended to concomitantly ingest aluminum-based antacids and deferiprone.
The safety of concurrent use of deferiprone and vitamin C has not been formally studied. Based on the reported adverse interaction that can occur between deferoxamine and vitamin C, caution should be used when administering deferiprone and vitamin C concurrently.
Incompatibilities: Not applicable.
Oral Solution: Drugs Associated with Neutropenia or Agranulocytosis: Avoid concomitant use of FERRIPROX with other drugs known to be associated with neutropenia or agranulocytosis; however, if this is not possible, monitor the absolute neutrophil count more frequently (see Oral Solution under Precautions).
UDP-Glucuronosyltransferases (UGTs): A clinical study to evaluate the effect of coadministration of UGT1A6 inhibitors with FERRIPROX on the systemic exposure of deferiprone has not been conducted. However, in the presence of the UDP glucuronosyltransferase (UGT) 1A6 inhibitor, phenylbutazone, the in vitro glucuronidation of deferiprone is reduced by 78%. Therefore, avoid concomitant use of UGT1A6 inhibitors (e.g. diclofenac, probenecid, or silymarin (milk thistle)) with FERRIPROX (see Oral Solution under Dosage & Administration, Oral Solution under Adverse Reactions, and Pharmacology: Pharmacodynamics: Oral Solution under Actions).
Polyvalent Cations: Concurrent use of FERRIPROX with foods, mineral supplements, and antacids that contain polyvalent cations has not been studied. However, since deferiprone has the potential to bind polyvalent cations (e.g., iron, aluminum, and zinc), allow at least a 4-hour interval between FERRIPROX and other medications (e.g., antacids), or supplements containing these polyvalent cations (see Oral Solution under Dosage & Administration).