Ferriprox Dosage/Direction for Use

FC tab: Deferiprone therapy should be initiated and maintained by a physician experienced in the treatment of patients with thalassemia.
Deferiprone is most commonly given as 25 mg/kg body weight orally 3 times a day for a total daily dose of 75 mg/kg body weight. Dosage per kilogram body weight should be calculated to the nearest half tablet.
To obtain a dose of about 75 mg/kg/day, use the number of tablets suggested: See Table 1.


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Doses ≥100 mg/kg/day are not recommended because of the potentially increased risk of adverse reactions.
Due to the serious nature of agranulocytosis that can occur with the use of deferiprone, special monitoring is required for all patients. Caution must be used when the patient's absolute neutrophil count (ANC) is low, as well as when treating patients with renal insufficiency or hepatic dysfunction.
DR tab: Deferiprone is most commonly given at a total daily dose of 75 mg/kg body weight, divided into two doses taken approximately 12 hours apart with food. Dosage per kilogram body weight should be calculated to the nearest half tablet. See Table 2 as follows.
Doses above 100 mg/kg/day are not recommended because of the potentially increased risk of adverse reactions.
Due to the serious nature of agranulocytosis that can occur with the use of deferiprone, special monitoring is required for all patients. Caution must be used when the patient's absolute neutrophil count (ANC) is low.
Dose table: To obtain a dose about 75 mg/kg/day, use the number of tablets suggested in the following table for the body weight of the patient. Sample body weights at 10 kg increments are listed. (See Table 2.)


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Oral Solution: Starting Dose: The recommended initial dose of FERRIPROX is 25 mg/kg, orally, three times per day for a total of 75 mg/kg/day. (See Table 3a.)


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Dose Adjustments: Dose adjustments should be tailored to the individual patient's response and therapeutic goals (maintenance or reduction of body iron burden). The maximum dose is 33 mg/kg, three times per day for a total of 99 mg/kg/day. The dose should be rounded by the prescriber to the nearest 2.5 mL. (See Table 3b.)


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Monitor serum ferritin concentration every two to three months to assess the effects of FERRIPROX on body iron stores. If the serum ferritin is consistently below 500 mcg/L, consider temporarily interrupting FERRIPROX therapy until serum ferritin rises above 500 mcg/L.
After first opening of the bottle, use within 35 days. Store the bottle in the original carton to protect from light. Store FERRIPROX only in the original container. After 35 days, discard the contents of the bottle. Store at 20º to 25ºC (68º to 77ºF); excursions permitted to 15º to 30ºC (59º to 86ºF).
Interactions with Foods, Vitamins and Drugs: Allow at least a 4-hour interval between FERRIPROX and other medications or supplements containing polyvalent cations such as iron, aluminum, and zinc. Avoid concomitant use of UGT1A6 inhibitors (e.g. diclofenac, probenecid, or silymarin (milk thistle)) with FERRIPROX (see Pharmacology: Pharmacokinetics: Oral Solution: Drug Interactions under Actions and Oral Solution under Interactions).