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Significant quantities of sulfadiazine can be absorbed after the long treatment of extensive burns.
SILVEDERMA cream should be used with caution in the presence of significant hepatic or renal impairment. Caution of use is required in patients known to be sensitive to systemic sulphonamides and in individuals known to have glucose-6-phosphate dehydrogenase deficiency.
The monitoring of the plasmatic levels of sulfadiazine is not necessary, except, possibly in patients with impaired hepatic or renal functions when the drug is applied to an extensive surface under occlusive bandage or to damaged skin (especially if burnt).
Should a massive absorption of the drug occur, its elimination through the urine should be enhanced with the help of the ingestion of abundant bicarbonated liquids.
In the event of serious crystalluria, urethral catheterization might be necessary.
