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Sulfadiazine absorption in SILVEDERMA application: Approximately 10% of the sulfadiazine contained in silver sulfadiazine is absorbed (5 g of silver sulfadiazine contains approximately 3 g of sulfadiazine).
In extensive burns, 500 g of cream can be applied, that means 5 g of silver sulfadiazine of which 0.3 g can be absorbed. This quantity cannot cause any renal problem. However, in patients with very extensive burns, sulfadiazine crystals can be observed in urine. Urine excretion of 50-100 ml/hour should be maintained, with the help of the appropriate administration of parenteral or oral liquids (electrolytic solutions, etc.).
It is necessary to be aware that the local absorption of substances in burns is very variable, because sometimes less active ingredients are absorbed through third-degree burns than through second-degree burns, possibly due to the presence of eschars in carbonized tissue.
