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Pregnancy: For PICOPREP, no clinical data on exposed pregnancy are available. Studies in animals have shown reproductive toxicity. As picosulfate is a stimulant laxative, for safety measure, it is preferable to avoid the use of PICOPREP during pregnancy.
Fertility: There are no data on the effect of PICOPREP on fertility in humans.
Male and female rat fertility was not affected by oral doses of sodium picosulfate up to 100 mg/kg.
Breastfeeding: There is no experience with the use of PICOPREP in nursing mothers. However, due to the pharmacokinetic properties of the active ingredients, treatment with PICOPREP may be considered for females who are breastfeeding.
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