Picoprep

Cleanse the bowel prior to X-ray exam or endoscopy. Cleanse the bowel prior to surgery when judged clinically necessary.

Adult Split-dose regimen (evening before & day of the procedure) Preferred method The day before the procedure: 1st reconstituted sachet is taken in the evening (eg, 5:00-9:00 PM) followed by at least five 250-mL drinks of clear liqd w/in 5 hr before bed. The day of the procedure: 2nd reconstituted sachet is taken approx 5 hr before the procedure followed by at least three 250-mL drinks of clear liqd. Clear liqd may be consumed w/in 5 hr up until 2 hr before the procedure. Day-before regimen (evening before the procedure only) 1st reconstituted sachet is taken in the afternoon or early evening (eg, 4:00-6:00 PM) followed by at least five 250-mL drinks of clear liqd w/in 5 hr before the next dose. 2nd reconstituted sachet is taken approx 6 hr later in the late evening (eg, 10:00 PM-12:00 AM) followed by three 250-mL drinks of clear liqd. Consume clear liqd w/in 5 hr before the procedure. Childn ≥9 yr Adult dose. 4-9 yr 1 sachet morning, ½ sachet afternoon. 2-4 yr ½ sachet morning & afternoon. 1-2 yr ¼ sachet morning & afternoon. First reconstituted dose to be taken before 8:00 AM on the day before the procedure followed by 2nd reconstituted dose 6-8 hr later.

Should be taken on an empty stomach.

Hypersensitivity. Congestive cardiac failure. Gastric retention, GI ulceration, toxic colitis, toxic megacolon, ileus, nausea & vomiting, acute surgical abdominal conditions (eg, acute appendicitis), known or suspected GI obstruction or perforation, severe dehydration, rhabdomyolysis, active inflammatory bowel disease. Hypermagnesemia. Severely reduced renal function.

Only administer before bowel surgery if clearly needed. Recent GI surgery, heart or inflammatory bowel disease. Concomitant use w/ drugs that might affect water &/or electrolyte balance eg, diuretics, corticosteroids & lithium. Ensure adequate oral intake of water & electrolytes particularly in less fit patients, childn, elderly, debilitated & those at risk of hypokalemia. Patients on antiepileptics, w/ previously controlled epilepsy; reduced kidney function or those on a controlled K diet. Period of bowel cleansing should not be >24 hr. Should not be taken by patients w/ galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Not to be used as a routine laxative. Preferable to avoid use during pregnancy. Lactation.

Headache, nausea & proctalgia; diarrhoea & faecal incontinence. Hyponatraemia w/ or w/o associated convulsions. Seizure/grand mal convulsion w/o associated hyponatraemia in epileptic patients.

May modify absorption of other orally administered medicines (eg, anti-epileptics, contraceptives, anti-diabetics, antibiotics). Chelation of Mg w/ tetracycline & fluoroquinolone, Fe, digoxin, chlorpromazine & penicillamine if not taken at least 2 hr before & not <6 hr after administration. Reduced efficacy w/ bulk-forming laxatives. Increased risk of hypokalemia w/ diuretics, corticosteroids or cardiac glycosides; water retention &/or electrolyte imbalance w/ NSAIDs, drugs known to induce SIADH eg, TCAs, SSRIs, antipsychotic drugs & carbamazepine.

Laxatives, Purgatives

A06AB58 - sodium picosulfate, combinations ; Belongs to the class of contact laxatives.

NP