Picoprep Dosage/Direction for Use

Method of administration: Route of administration: Oral.
There are two dosing regimens, each requires two separate dosing times: The preferred method is the "Split Dose" method and consists of two separate doses: the first dose during the evening before the procedure and the second dose the next day, during the morning prior to the procedure.
The alternative method is the "Day Before" method and consists of two separate doses: the first dose during the afternoon or early evening before the procedure and the second dose 6 hours later during the evening before the procedure.
A low residue diet is recommended on the day prior to the procedure. A clear liquid diet is recommended on the day of the procedure. To avoid dehydration, it is important to follow the liquid intake recommendation as advocated together with the PICOPREP dosing whilst the effects of PICOPREP persist (see Posology as follows). Apart from the liquid intake together with the treatment regimen (PICOPREP + additional liquids), a normal, thirst driven intake of clear liquids is recommended.
Clear liquids should include a variety of fruit juice without pulp, soft drinks, clear soup, tea, coffee (without milk, soy or cream) and water. Do not drink only water.
Directions for Reconstitution: (a) Reconstitute the PICOPREP powder right before each administration. Do not prepare the solution in advance.
(b) Fill a cup with cold water (approximately 150 ml) and pour in the contents of one packet of PICOPREP powder.
(c) Stir for 2 to 3 minutes. The reconstituted PICOPREP solution may become slightly warm as the powder dissolves.
Posology: Split-Dose Dosing Regimen (Preferred Method): The Split-Dose regimen is the preferred dosing method. Instruct patients to take two separate doses in conjunction with fluids, as follows: Take the first dose during the evening before the procedure (e.g., 5:00 to 9:00 PM) followed by at least five 250 ml drinks of clear liquids before bed. Consume clear liquids within 5 hours.
Take second dose, the next day approximately 5 hours before the procedure followed by at least three 250 ml drinks of clear liquids before the procedure. Consume clear liquids within 5 hours up until 2 hour before the time of the procedure.
Day-Before Dosing Regimen (Alternative Method): The Day-Before regimen is the alternative dosing method for patients for whom the Split-Dosing is inappropriate. Instruct patients to take two separate doses in conjunction with fluids, as follows: Take the first dose in the afternoon or early evening (e.g., 4:00 to 6:00 PM) before the procedure followed by at least five 250 ml drinks of clear liquids before the next dose. Consume clear liquids within 5 hours.
Take the second dose approximately 6 hours later in the late evening (e.g., 10:00 PM to 12:00 AM), the night before the procedure followed by three 250 ml drinks of clear liquids before bed. Consume clear liquids within 5 hours.
Children: The first dose reconstituted in water as directed, taken before 8 am on the day before the procedure. Second dose 6 to 8 hours later.
1 - 2 years: ¼ sachet morning, ¹/₄ sachet afternoon.
2 - 4 years: ½ sachet morning, ¹/₂ sachet afternoon.
4 - 9 years: 1 sachet morning, ¹/₂ sachet afternoon.
9 and above: adult dose.