Viartril-S Drug Interactions

No specific drug interaction studies have been performed. However, the physicochemical and pharmacokinetic properties of glucosamine sulfate suggest a low potential for interactions. In addition glucosamine sulfate was found not to inhibit or to induce any of the major human CYP450 enzymes. In fact, the compound does not compete for absorption mechanisms and, after absorption, does not bind to plasma proteins, while its metabolic fate as an endogenous substance incorporated in proteoglycans or degraded independently of the cytochrome enzyme system, is unlikely to give rise to drug interactions. Due to the limited amount of information regarding drug interactions. Should be aware about the use with other drugs.
An increased effect of coumarinic anticoagulants during concomitant treatment with glucosamine sulfate has been reported. Therefore, a closer monitoring of the coagulation parameters may be considered in these patients when initiating or ending glucosamine therapy.
The oral administration of glucosamine sulfate can enhance the gastrointestinal absorption of tetracyclines but the clinical relevance of this interaction is probably limited.