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Cases of Insulin Autoimmune Syndrome (IAS) have been reported during treatment with alpha-lipoic acid. Patients with human leukocyte antigen genotype such as HLA-DRB1*04:06 and HLA-DRB1*04:03 alleles, are more susceptible to develop IAS when treated with alpha-lipoic acid. HLA-DRB1*04:03 allele (susceptibility to IAS odds ratio: 1.6) is especially found in Caucasians, with a higher prevalence in southern than in northern Europe and HLA-DRB1*04:06 allele (susceptibility to IAS odds ratio: 56.6) is especially found in Japanese and Korean patients.
IAS should be considered in the differential diagnosis of spontaneous hypoglycaemia in patients using thioctic acid (see Adverse Reactions).
This product contains lactose. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicinal product.
Effects on the Ability to Drive and Use Machines: No particular precautionary measures are required.
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