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Silodosin is alpha-adrenergic blocker. Overdose results in excessive vasodilation cause hypotension and reflex tachycardia.
Hypotension usually responds to IV fluids. Hypotension that does not respond to IV fluids should be treated with adrenergic vasopressors.
Patients who are awake after a significant ingestion should be treated with activated charcoal to limit the potential for symptomatic hypotension.
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