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Nicergoline should be administered cautiously with drugs listed as follows: Antihypertensive drugs: Nicergoline may potentiate the effect of antihypertensive drugs. Nicergoline may potentiate the cardiac effect of beta blocking agents.
Sympathomimetic drugs (alpha and beta): Nicergoline may antagonize the vasoconstrictor effect of sympathomimetic drugs due to its alpha-adrenergic blocking effect (see Precautions).
Drugs metabolized by CYP 2D6: Since nicergoline is metabolized through CYP 2D6, an interaction with drugs undergoing the same pathway cannot be excluded.
Antiaggregant and anticoagulant drugs (e.g., acetylsalicylic acid): Increases the effect on hemostasis, therefore, bleeding period may be prolonged.
Drugs that influence uric acid metabolism: Since nicergoline may increase asymptomatic increase of serum uric acid levels. Caution should be used in administering the drug in patients with hyperuricemia or with a history of gout and/or under treatment with drugs that might be able to interfere with the metabolism and excretion of uric acid.
