Norepirin Drug Interactions

Cyclopropane and halothane anesthetics increase cardiac autonomic irritability and therefore seem to sensitize the myocardium to the action of intravenously administered epinephrine or norepinephrine. Hence, the use of Norepinephrine bitartrate injection during cyclopropane and halothane anesthesia is generally considered contraindicated because of the risk of producing ventricular tachycardia or fibrillation. The same type of cardiac arrhythmias may result from the use of Norepinephrine bitartrate injection in patients with profound hypoxia or hypercarbia.
Norepinephrine bitartrate injection should be used with extreme caution in patients receiving monoamine oxidase inhibitors (MAOI) or antidepressants of the triptyline or imipramine types, because severe prolonged hypertension may result.
The levels/effects of Norepinephrine may be increased by Serotonin/Norepinephrine Reuptake Inhibitors.
The levels/effects of Norepinephrine may be decreased by Spironolactone.