Norepirin Dosage/Direction for Use

Acute hypotension: For single dose, dilute 8 mg of norepinephrine bitartrate (eq. to norepinephrine 4 mg) in 1,000 mL of dextrose 5% injection or 0.9% normal saline, and administer in a ratio of 2-3 mL/min by intravenous drip. Monitor closely while administering and increase or decrease the dose. The maintenance dose is 0.5-1.0 mL/min and this is different with each individual.
As a result of the in-use stability test, it can be kept 24 hours after mixing at the temperature 30°C.
Cardiac arrest: During the cardiac resuscitation, secure effective heart beat with ventilation, then administer intravenously same as for acute hypotension.
Geriatric patient: Clinical studies of norepinephrine bitartrate did not include sufficient numbers of patients 65 years of age and older to determine whether geriatric patients respond differently than younger patients. Clinical experience to date has not identified any differences in responses between geriatric and younger patients. If norepinephrine is used in geriatric patients, dosage should be selected carefully, usually starting at the low end of the dosage range, since renal, hepatic, and cardiovascular dysfunction and concomitant disease or other drug therapy are more common in this age group. Norepinephrine infusions should not be administered into leg veins in geriatric patients.