Hofmax Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Warnings Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Thai FDA Category Presentation/Packing Local Product Insert

Concise Prescribing Info

Contents

Azithromycin

Indications/Uses

Acute bacterial exacerbations of COPD, acute bacterial sinusitis & acute otitis media caused by H. influenzae, M. catarrhalis, S. pneumoniae. Community-acquired pneumonia (CAP) caused by H. influenzae, M. pneumoniae, S. pneumoniae, Chlamydophila pneumoniae. Genital ulcer disease (chancroid) in men caused by Haemophilus ducreyi. Pharyngitis/tonsillitis caused by S. pyogenes. Uncomplicated skin & skin structure infections caused by S. aureus, S. pyogenes, Strep agalactiae. Urethritis & cervicitis caused by Chlamydia trachomatis, Neisseria gonorrhoeae.

Click to view Hofmax detailed prescribing information

Dosage/Direction for Use

Adult Acute bacterial exacerbations of COPD (mild to moderate severity) Usual dose: 500 mg/day for 3 days; alternative dose: 500 mg as single dose on the 1st day followed by 250 mg once daily on days 2-5. Acute bacterial sinusitis 500 mg/day for 3 days. CAP (mild severity), pharyngitis/tonsillitis (as 2nd-line therapy), uncomplicated skin/skin structure infections 500 mg as single dose on the 1st day followed by 250 mg once daily on days 2-5. Genital ulcer disease (chancroid), non-gonococcal urethritis/cervicitis 1 g as single dose. Gonococcal urethritis/cervicitis 2 g as single dose. Childn ≥2 yr Pharyngitis/tonsillitis Usual dose: 12 mg/kg once daily for 5 days. Max dose: 500 mg/day, ≥6 mth Acute bacterial sinusitis 10 mg/kg once daily for 3 days. Acute otitis media Usual dose: 30 mg/kg as single dose; alternative dose: 10 mg/kg once daily for 3 days or 10 mg/kg as single dose on the 1st day followed by 5 mg/kg on days 2-5. CAP 10 mg/kg as single dose on the 1st day followed by 5 mg/kg on days 2-5.

Click to view Hofmax detailed prescribing information

Overdosage

View Hofmax overdosage for action to be taken in the event of an overdose.

Administration

May be taken with or without food.

Contraindications

Hypersensitivity to azithromycin or other macrolide antibiotics.

Click to view Hofmax detailed prescribing information

Warnings

For additional cautionary notes to warn of the potential risk of using the medicine... Click to view Hofmax detailed prescribing information

Special Precautions

Hypersensitivity. May cause liver damage. Discontinue in symptoms of malaise, nausea, vomiting abdominal colic & fever. Reappearance of allergic reaction. May mask or delay symptoms of incubating gonorrhea or syphilis; perform appropriate culture & susceptibility tests prior to initiating treatment. Prolonged use may result in fungal or bacterial superinfection, eg, C. difficile-associated diarrhea & Pseudomembranous colitis. Patients at risk of prolonged cardiac repolarization; w/ myasthenia gravis; preexisting liver disease; hepatic impairment w/ or w/o jaundice. Renal dysfunction; patients w/ GFR <10 mL/min. Pregnancy & lactation.

Click to view Hofmax detailed prescribing information

Use In Pregnancy & Lactation

Click to view Hofmax detailed prescribing information

Adverse Reactions

Diarrhea, nausea, abdominal pain, anorexia, cramping, vomiting, oral candidiasis; pruritus, rash; vaginitis, acute renal failure; arrhythmias, hypotension; aggressive reaction, anxiety, hyperactivity, paresthesia, syncope; thrombocytopenia; cholestatic jaundice; hearing disturbances (eg, deafness &/or tinnitus), taste loss & smell perversion; arthralgia, edema.

Click to view Hofmax detailed prescribing information

Drug Interactions

Avoid concomitant use w/ artemether, BCG, dronedarone, lumefantrine, nilotinib, pimozide, quinine, tetrabenazine, thioridazine & ziprasidone. May increase effects of cardiac glycosides, cyclosporine, dronedarone, pimozide, QTc-prolonging agents, quinine, tacrolimus, tetrabenazine, thioridazine, vit K antagonist & ziprasidone. Effect may be increased by alfuzosin, artemether, chloroquine, ciprofloxacin, conivaptan, gadobutrol, lumefantrine, nilotinib & quinine. May decrease effects of BCG & typhoid vaccine.

Click to view Hofmax detailed prescribing information

Storage

View Hofmax storage conditions for details to ensure optimal shelf-life.

Description

View Hofmax description for details of the chemical structure and excipients (inactive components).

Action

View Hofmax mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Macrolides

ATC Classification

J01FA10 - azithromycin ; Belongs to the class of macrolides. Used in the systemic treatment of infections.

Thai FDA Category

Presentation/Packing

Form

Hofmax cap 250 mg

Packing/Price

1 × 6's

Hofmax

azithromycin

Manufacturer:

Pharmahof

Distributor:

Pharmahof