Diclegis Special Precautions

Diclegis may cause somnolence due to the anticholinergic properties of doxylamine succinate, an antihistamine (see Adverse Reactions).
Use of Diclegis is not recommended if a woman is concurrently using central nervous system (CNS) depressants including alcohol (see Interactions).
Diclegis has anticholinergic properties and, therefore, should be used with caution in patients with: asthma, increased intraocular pressure, narrow angle glaucoma, stenosing peptic ulcer, pyloroduodenal obstruction and bladder-neck obstruction.
Diclegis contains pyridoxine hydrochloride, a vitamin B6 analog, therefore additional levels from diet and vitamin B6 supplements should be assessed.
Diclegis contains traces of the azo colouring agent Allura Red AC Aluminium Lake (E129) which may cause allergic reactions.
There is limited evidence in cases of hyperemesis gravidarum for the combination doxylamine/pyridoxine. These patients should be treated by a specialist.
There have been reports of false positive urine screening tests for methadone, opiates, and phencyclidine phosphate (PCP) with doxylamine succinate/pyridoxine hydrochloride use (see Interactions).
Effects on ability to drive and use machines: Diclegis has a moderate to major influence on the ability to drive and use machines.
Women should avoid engaging in activities requiring complete mental alertness, such as driving or operating heavy machinery, while using Diclegis until cleared to do so by their healthcare provider.