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Monoamine oxidase inhibitors: Monoamine oxidase inhibitors (MAOIs) prolong and intensify the anticholinergic effects of antihistamines.
Central nervous system depressants: Concurrent use with central nervous system (CNS) depressants including alcohol, hypnotic sedatives and tranquilizers is not recommended. The combination may result in severe drowsiness.
Food: A food-effect study has demonstrated that the delay in the onset of action of Diclegis may be further delayed, and a reduction in absorption may occur when tablets are taken with food. Therefore, Diclegis should be taken on an empty stomach with a glass of water (see Dosage & Administration).
Interference with urine screen for Methadone, Opiates and PCP: False positive urine drug screens for methadone, opiates, and PCP can occur with doxylamine succinate/pyridoxine hydrochloride use. Confirmatory tests, such as Gas Chromatography Mass Spectrometry (GC-MS), should be used to confirm the identity of the substance in the event of a positive immunoassay result.
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