ChiroRab Special Precautions

There is not, as a rule, an increased risk during immunisation with ChiroRab in subjects who state that they are "allergic to chicken protein" or who exhibit a positive reaction in the chicken protein skin test.
In the extremely rare cases in which subjects have reacted with clinical symptoms such as urticaria (nettle rash), lip and epiglottis oedema (inflammatory swelling of the lips and larynx region), laryngo- or bronchospasm (spasm of the glottis or bronchial muscles), a fall in blood pressure, or shock after eating chicken protein, the immunisation should be conducted only under close clinical monitoring, and with the appropriate facilities for emergency treatment available.
ChiroRab contains polygeline and may contain residual amounts of the antibiotics amphotericin B, chlotetracycline, neomycin and this could potentially cause allergic reactions.
In patients with known hypersensitivity to the constitutents of the vaccine receiving post-exposure treatment, appropriate medical treatment addressing anaphylactic shock should always be on-hand during vaccination, or alternatively another equivalent modern cell culture rabies vaccine should be used.
Minor infections (even with subfebrile temperatures (≤ 38.5°C)) are not a contraindication, nor is possible contact with individuals suffering from infectious diseases.
Do not administer by intravascular injection!
If the vaccine is inadvertently administered intravascularly (in a blood vessel), there is a risk of adverse reactions, with shock potentially occurring in extreme cases. Appropriate emergency measures to prevent shock must be taken immediately.
Do not mix vaccine with rabies immunoglobuhn in the same syringe.
After contact with animals which are suspected earners of rabies, it is essential to observe the following procedures: Immediate wound treatment: First aid: In order to remove as much of the rabies virus as possible, immediately cleansed the wound with soap and flush thoroughly with water. Then treat with alcohol (70 %) or an iodine tincture.
Where possible, wounds should not be closed with a suture, or only sutured to secure apposition. Prophylaxis against tetanus should be administered when necessary!
In cases in which simultaneous administration of vaccine and immunoglobulin is indicated, as much of the recommended dose of human rabies immunoglobulin as is anatomically feasible should be applied as deeply as possible in and around the wound. Any remaining immunoglobulin should be injected intramuscularly at a site distant from the site of vaccine administration, preferably intragluteally (in the gluteal muscle).