CYP3A4 and CYP2D6 inhibitors may inhibit donepezil metabolism. Reduced levels with rifampicin, phenytoin, carbamazepine. May interfere with drugs having anticholinergic activity. Concomitant use with succinylcholine, other neuromuscular and β-blocking agents, & cholinergic agonists may produce synergistic activity on cardiac conduction.
Sign Out
