Annie Special Precautions

Inform the doctor if the patient suffers from any of the following disorders: diabetes, high blood pressure, varicose veins, otosclerosis, multiple sclerosis, epilepsy, porphyria, tetany, chorea minor. In all these cases, and also where there is a history of phlebitis, or a tendency to diabetes, ANNIE may only be taken under strict medical supervision.
If the patient is taking other medical preparations regularly (for example, barbiturates, phenylbutazone, hydantoins, rifampicin, ampicillin), since they can impair the action of ANNIE. Insulin and antidiabetic requirements may change.
Reasons for Immediate Discontinuation of Annie: Occurrence for the first time of migrainous headaches or more frequent occurrence of unusually severe headaches, sudden perceptual disorders (e.g. disturbances of vision or hearing), first signs of thrombophlebitis or thromboembolic symptoms (for example, unusual pains in or swelling of the legs, stabbing pains on breathing or coughing for no apparent reason), a feeling of pain and tightness in the chest, pending operations (six weeks before hand), immobilization (for instance, following accidents). In all these cases there may be an increased risk of thrombosis. Further reasons for discontinuation are: onset of jaundice, onset of hepatitis, itching of the whole body, increase in epileptic seizures, significant rise in blood pressure, pregnancy.