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Allora Syrup: Pharmacology: Pharmacodynamics: Desloratadine is a long-acting tricyclic histamine antagonist with selective H1-receptor histamine antagonist activity. Desloratadine shows significant interaction with the human histamine H1-receptor. Desloratadine inhibited histamine release from human mast cell in vitro.
Pharmacokinetics: Absorption: There was no effect of food on the absorption of desloratadine.
Distribution: Vd of children is 686 to 1565 L.
Metabolism: Desloratadine is extensively metabolized in liver via CYP2C8-mediated hydroxylation. 3-Hydroxydesloratadine is active metabolite. Desloratadine is a substrate of CYP2C8.
Excretion: 46.5% of drug was excreted in feces as metabolites. 40.6% of drug was excreted by kidney, primarily as metabolites.
Elimination half-life: Half-life in children is 16 to 19 hours.
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