ACC Sandoz Special Precautions

The occurrence of severe skin reactions such as Stevens-Johnson syndrome and Lyell's syndrome has very rarely been reported in temporal connection with the use of acetylcysteine. If cutaneous and mucosal changes newly occur, medical advice should be sought without delay and use of acetylcysteine be terminated (see also Adverse Reactions).
Cave during use in patients with bronchial asthma and in patients with anamnestic ulcers.
Caution is advised in patients with histamine intolerance. Longer-term therapy should be avoided in these patients, as Acetylcysteine has an effect on histamine metabolism and may lead to symptoms of intolerance (e.g. headache, vasomotor rhinitis, itching).
The use of acetylcysteine, especially in early treatment can lead to liquefaction and thus to an increase in volume of bronchial secretions. If the patient is unable to cough up enough of this, appropriate measures (such as postural drainage and aspiration) should be performed.
Acetylcysteine Sandoz contains sorbitol, lactose and sodium.
200 mg: This medicinal product contains up to 20 mg sorbitol in each effervescent tablet. Patients with hereditary fructose intolerance (HFI) should not take this medicinal product.
This medicinal product contains 70 mg lactose per effervescent tablet. Patients with rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption should not take this medicinal product.
This medicinal product contains 4.3 mmol (99 mg) sodium per effervescent tablet, equivalent to 5% of the WHO recommended maximum daily intake of 2 g sodium for an adult.
600 mg: This medicinal product contains up to 40 mg sorbitol in each effervescent tablet.
This medicinal product contains 70 mg lactose per effervescent tablet. Patients with rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption should not take this medicinal product.
This medicinal product contains 6.0 mmol (139 mg) sodium per effervescent tablet, equivalent to 7% of the WHO recommended maximum daily intake of 2 g sodium for an adult.
Effects on ability to drive and use machines: Acetylcysteine has no influence on the ability to drive and use machines.