Tadafil Dosage/Direction for Use

Posology: Erectile Dysfunction: Tadalafil for Use as Needed: The recommended dose is 10 mg taken prior to anticipated sexual activity. In those patients in whom tadalafil 10 mg does not produce an adequate effect, the maximum dose is 20 mg and the maximum dosing frequency is once per day. It may be taken from 30 minutes to 36 hours prior to sexual activity. Tadalafil 10 mg and 20 mg is intended for use prior to anticipated sexual activity and it is not recommended for continuous daily use.
Tadalafil for Once Daily Use: In patients who anticipate a frequent use of Tadalafil (i.e. at least twice weekly) a once daily regimen with the lowest doses of Tadalafil might be considered suitable, based on patient choice and the physician's judgement. In these patients the recommended starting dose is 2.5 mg once a day, taken at approximately the same time every day, without regard to timing of sexual activity. The dose may be increased to 5 mg once a day, based on individual efficacy and tolerability. The appropriateness of continued use of the daily regimen should be reassessed periodically.
Benign Prostatic Hyperplasia: The recommended dose is 5 mg, taken at approximately the same time every day. When therapy for BPH is initiated with Tadalafil and finasteride, the recommended dose of Tadalafil is 5 mg, taken at approximately the same time every day for up to 26 weeks.
Erectile Dysfunction and Benign Prostatic Hyperplasia: The recommended dose is 5 mg, taken at approximately the same time every day, without regard to timing of sexual activity.
Elderly men: Dose adjustments are not required in elderly patients.
Men with renal impairment: Tadalafil for Use as Needed: Mild (creatinine clearance 51 to 80 ml/min): No dose adjustment is required.
Moderate (creatinine clearance 31 to 50 ml/min): A starting dose of 5 mg not more than once per day is recommended and the maximum dose is 10 mg not more than once in every 48 hours.
Severe (creatinine clearance < 30 ml/min or on hemodialysis): The maximum dose is 5 mg not more than once in every 72 hours (see Precautions and Pharmacology: Pharmacokinetics under Actions).
Tadalafil for Once Daily Use: Mild (creatinine clearance 51 to 80 ml/min): No dose adjustment is required.
Moderate (creatinine clearance 31 to 50 ml/min): No dose adjustment is required.
Severe (creatinine clearance < 30 ml/min or on hemodialysis): Tadalafil for once daily use is not recommended (see Precautions and Pharmacology: Pharmacokinetics under Actions).
Men with hepatic impairment: Tadalafil for Use as Needed: The recommended dose is 10 mg taken prior to anticipated sexual activity. There is limited clinical data on the safety of Tadalafil in patients with severe hepatic impairment (Child-Pugh Class C); if prescribed, a careful individual benefit/risk evaluation should be undertaken by the prescribing physician. There are no available data about the administration of doses higher than 10 mg of tadalafil to patients with hepatic impairment.
Tadalafil for Once Daily Use: Once-a-day dosing has not been extensively evaluated in patients with hepatic impairment; therefore, if prescribed, a careful individual benefit/risk evaluation should be undertaken by the prescribing physician (see Precautions and Pharmacology: Pharmacokinetics under Actions).
Men with diabetes: Dose adjustments are not required in diabetic patients.
Paediatric population: Tadalafil should not be used in individuals below 18 years of age.
Patients taking CYP3A4 Inhibitors: Tadalafil for Use as Needed: For patients taking concomitant potent inhibitors of CYP3A4, such as ketoconazole or ritonavir, the maximum recommended dose of Tadalafil is 10 mg, not to exceed once every 72 hours (see Precautions and Interactions).
Tadalafil for Once Daily Use: For patients taking concomitant potent inhibitors of CYP3A4, such as ketoconazole or ritonavir, the maximum recommended dose of Tadalafil is 2.5 mg (see Precautions and Interactions).
Method of administration: For oral use. Tadalafil can be taken with or without food.