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Pregnancy: There are no adequate and well-controlled studies in pregnant women. Propafenone hydrochloride should be prescribed during pregnancy only if the potential benefit justifies the potential risk to the fetus. Propafenone hydrochloride is known to pass the placental barrier in humans. The concentration of propafenone in the umbilical cord has been reported to be about 30% of that in the maternal blood.
Lactation: Excretion of propafenone in human breast milk has not been studied. Limited data suggests that propafenone may be excreted in human breast milk. Propafenone hydrochloride should be used with caution in nursing mothers.
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