Known hypersensitivity to propafenone hydrochloride or to any of the excipients.
Known Brugada Syndrome (see Precautions).
Incident of myocardial infarction within the last 3 months.
Significant structural heart disease such as: uncontrolled congestive heart failure where left ventricular output is less than 35%; cardiogenic shock (unless this is caused by arrhythmia); severe symptomatic bradycardia; presence of sinus node dysfunction, atrial conduction defects, second degree or greater atrioventricular block or bundle branch block or distal block in the absence of an artificial pacemaker; severe hypotension.
Manifest electrolyte imbalance (e.g. potassium metabolism disorders).
Severe obstructive pulmonary disease.
Myasthenia gravis.
Concomitant treatment with ritonavir.