Rectogesic Drug Interactions

Interaction with other drugs: Concomitant use of alcohol may enhance vascular effects.
Concomitant treatment with other vasodilators, calcium channel blockers, ACE inhibitors, and beta-blockers may potentiate the blood pressure lowering effects of Rectogesic.
Acetyl cysteine may potentiate the vasodilatory effects of glyceryl trinitrate.
Concomitant treatment with heparin leads to a decrease in heparin efficacy. Close monitoring of blood coagulation parameters is necessary and the dose of heparin has to be adapted accordingly. After withdrawal of Rectogesic there may be an abrupt increase in PPT. In this case reduction of heparin dosage may be necessary.
Concurrent administration of glyceryl trinitrate may cause a reduction of the thrombolytic activity of alteplase.
Co-administration of Rectogesic with dihydroergotamine may increase the bioavailability of dihydroergotamine and lead to coronary vasoconstriction.
The possibility that the ingestion of acetylsalicylic acid and NSAIDs might diminish the therapeutic response to Rectogesic cannot be excluded.