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Mefenamic acid may prolong prothrombin time. Therefore, when the drug is administered to patients receiving oral anti-coagulant drugs, frequent monitoring of prothrombin time is necessary.
Orphenadrine has been shown to induce enzymatic systems involving the metabolism of aminopyrine, steroidal contraceptives, griseofulvin, hexobarbital and phenylbutazone. Orphenadrine will potentiate other anticholinergic agents.
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