Neurobion

It is a white, round, biconvex coated tablet.
Each coated tablet contains, as active ingredients, 100 mg vitamin B₁ (thiamine disulfide), 200 mg vitamin B₆ (pyridoxine hydrochloride), 200 mcg vitamin B₁₂ (cyanocobalamin).
Excipients/Inactive Ingredients: montan-glycol wax, acacia, povidone, methylcellulose, magnesium stearate, purified water, calcium carbonate, glycerol, mannitol, colloidal anhydrous silica, kaolin, gelatin, titanium dioxide (E 171), sodium starch glycolate, talc, sucrose.

Neurobion is a combination of 3 essential neurotropic vitamins (B₁, B₆ and B₁₂) in high dosage. Vitamins B₁, B₆ and B₁₂ are of special importance for the metabolism in the peripheral and central nervous system. Their effect on the regeneration of nerves has been shown in various investigations using the vitamins individually and in combination.
Vitamin B₁ plays an important role in major metabolic processes. Vitamin B₆ has an analgesic effect. Vitamin B₁₂ ensures blood cell formation and prevents degenerative processes of the nervous system. Both the individual function and the beneficial biochemical links between the 3 vitamins justify their combined use.

It is indicated for nerve pain expressed in one or more of the following symptoms: pricking/tingling sensation, numbness, muscle stiffness, muscle cramp, impaired sensation.

Adults: One tablet 3 times daily. Do not take NEUROBION for more than 6 months without a doctor's supervision.
To be swallowed without chewing with a little liquid with or after meals.
Stop use and consult a doctor if symptoms persists.
What should the patient do if he/she missed a dose: Take the missed dose as soon as the patient remembers.
Skip the missed dose if it is almost time for the next scheduled dose.
Do not take extra medicine to make up the missed dose.

Signs and symptoms of over dosage: Prolonged overdose of vitamin B₆ i.e. for longer than 2 months and more than 1g per day, may lead to neurotoxic effects.
No cases of overdose with thiamine or cyanocobalamin have been described. Sensorial neuropathy and other sensorial neuropathy syndromes which can be caused by long-term administration of high doses of pyridoxine improve gradually upon vitamin discontinuation.
If the patient notices any unusual symptoms of peripheral sensory neuropathy (sensation of tingling, tickling, prickling, pricking, or burning), tell the doctor immediately.
What to do when the patient had taken more than the recommended dosage: If the patient (or someone else) swallow a lot of tablets at the same time, or a child may have swallowed any, stop taking the product and contact the nearest hospital casualty department or tell the doctor immediately.

Hypersensitivity to any of the active ingredients or excipients of the product .
Not suitable for the treatment of children due to the high content of active ingredients.

Long term usage: Neuropathies are described in the literature following long term intake (6-12 months) of more than 50mg mean daily dose of vitamin B₆. Consult a doctor if the patient is taking NEUROBION daily over a prolonged period. Regular monitoring is recommended under long-term treatment. If the patient has any new symptoms, then stop the treatment and talk to the doctor.
When to consult a doctor or pharmacist: NEUROBION tablet contain sucrose; therefore its use is not recommended in patients with rare hereditary galactose or fructose intolerance, glucose-galactose malabsorption, Lapp lactase deficiency, or sucrase-isomaltase insufficiency.
Tell the doctor or pharmacist if the patient is taking or has recently taken any other medicines, especially levodopa (for Parkinson's disease) or medicines obtained without a prescription.
If the patient has been told he/she has an intolerance to some sugars, contact the doctor before taking this medicine, as it contains sucrose.
Long term intake of vitamin B₁₂ may improve folate-deficient megaloblastic anaemia and care should be taken that a correct diagnosis is not masked.
Stop use and consult a doctor if symptoms persists.
Effects on the ability to drive and use machines: NEUROBION tablet has no influence on the ability to drive and use machines.
Use in Pregnancy & Lactation: If the patient is pregnant particularly in the first three months, planning to become pregnant or are breast-feeding, speak to the doctor or pharmacist before taking this medicine.

No risks have become known associated with the use of NEUROBION tablet during pregnancy at the recommended dosage.
Vitamins B₁, B₆ and B₁₂ are secreted into human breast milk, but risks of overdose for the infant are not known. In individual cases, high doses of vitamin B₆ ie, >600 mg daily, may inhibit the production of breast milk.

(See table.)

Click on icon to see table/diagram/image

L-dopa: The effect of L-dopa may be reduced when vitamin B₆ is administered concomitantly.
Pyridoxine-antagonists, eg, isoniazid (INH), cycloserine, penicillamine, hydralazine: The efficacy of vitamin B₆ may be decreased.
Loop diuretics eg, furosemide: In long-term use, the blood level of vitamin B₁ may be reduced. Avoid taking any preparations (e.g. supplements) that include vitamin B₆ (pyridoxine) together with NEUROBION.

Medicines should not be disposed of via wastewater or household waste. Ask the pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

Store in a dry place, below 25°C.

Vitamin B-Complex / with C

A11DB - Vitamin B1 in combination with vitamin B6 and/or vitamin B12 ; Used as dietary supplements.

GSL