Irinox Description

Each ml contains: Irinotecan Hydrochloride Trihydrate equivalent to Irinotecan 20 mg.
Irinotecan Hydrochloride concentrate for solution for injection an antineoplastic agent of the topoisomerase I inhibitor class.
Irinotecan hydrochloride is a pale yellow to yellow crystalline powder. Irinotecan Hydrochloride concentrate for solution for injection is available in 40 mg (2 ml) and 100 mg (5 ml) multi dose vials. Each ml contains irinotecan hydrochloride trihydrate, 20 mg; sorbitol, 45 mg; lactic acid, 0.9 mg; water for injection, q.s.
Irinotecan hydrochloride is a semisynthetic derivative of camptothecin, an alkaloid extract from plants such as Camptotheca acuminata or is chemically synthesized.
The chemical name is (S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinolin-9-yl-[1,4'bipiperidine]-1'-carboxylate, monohydrochloride, trihydrate. Its empirical formula is C₃₃H₃₈N₄O₆•HCl•3H₂O and molecular weight is 677.19. It is slightly soluble in water and organic solvents.