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Hypoglycaemia has not been seen with metformin doses of up to 85 g, although lactic acidosis has occurred in such circumstances. High overdose or concomitant risks of metformin may lead to lactic acidosis. Lactic acidosis is a medical emergency and must be treated in hospital. The most effective method to remove lactate and metformin is haemodialysis.
Glucophage XR: In a patient with lactic acidosis who is taking Glucophage XR, the drug should be discontinued immediately and general supportive measures promptly instituted.
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