Beprosalic

Each gram of Beprosalic Ointment contains Betamethasone dipropionate 0.064% w/w, (equivalent to 0.05% w/w of betamethasone), and 3% w/w Salicylic acid in a paraben free ointment base of white soft paraffin and liquid paraffin.

Pharmacology: Pharmacodynamics: Betamethasone dipropionate is a topically active fluorinated corticosteroid which has anti-inflammatory, anti-pruritic and vasoconstrictive actions. Salicylic acid has keratolytic properties, as well as bacteriostatic and fungicidal actions.
Pharmacokinetics: When administered topically, particularly under occlusive dressing or when the skin is broken, sufficient corticosteroid may be absorbed to give systemic effects. Corticosteroids are extensively bound to plasma proteins. Only unbound corticosteroid has pharmacological effects or is metabolized. They are metabolized mainly in the liver, also in the kidney and are excreted in the urine. When salicylic acid is administered topically to large areas of the body, it may cause symptoms of acute systemic salicylate poisoning.

For the relief of the inflammatory manifestations of hyperkeratotic and dry corticosteroid-responsive dermatoses which include psoriasis, chronic atopic dermatitis, neurodermatitis and seborrhoeic dermatitis.

Wash and dry affected area. Apply sparingly to the affected areas and rub in twice daily, morning and evening or as directed.

Symptoms: Excessive prolonged use of topical corticosteroids can suppress pituitary-adrenal functions resulting in secondary adrenal insufficiency. Excessive prolonged use of topical preparations containing Salicylic acid may cause symptoms of salicylism.
Treatment: Appropriate symptomatic treatment is indicated. Acute hypercorticoid symptoms are virtually reversible.
Treat electrolyte imbalance, if necessary. In cases of chronic corticosteroid toxicity, slow withdrawal of steroids is advised. Treatment of salicylism is symptomatic. Measures should be taken to rid the body of salicylate. Administer oral sodium bicarbonate to alkalinize and force diuresis.

Hypersensitivity to Betamethasone dipropionate, other corticosteroids, Salicylic acid, or other salicylates, or any component in the base. Topical corticosteroids are contraindicated in most viral infections of the skin and also tuberculosis and acne rosacea.

Discontinue use if irritation, sensitivity, excessive dryness or other reactions develop. In the presence of infection appropriate treatment should be given. Corticosteroids applied topically can be absorbed in sufficient amount to produce systemic effects like adrenal suppression, manifestation of Cushing's syndrome, hyperglycaemia and glucosuria in some patients, particularly in infants and children. Salicylic acid in preparations applied to the skin can also be absorbed in sufficient amounts to produce salicylism. Therefore suitable precautions must be taken with Beprosalic Ointment during prolonged treatment, when treating extensive body surface areas, when using the occlusive technique and when treating children (because of a larger skin surface area to bodyweight ratio). Suitable precautions must be taken when treating stasis dermatitis and other skin diseases with impaired circulation. Discontinue use if irritation, sensitivity or other reactions develop and institute appropriate treatment. Not suitable for ophthalmic use.
Do not use in or around the eyes.

Safety of its use during pregnancy and lactation has not been established. Thus it should be used only if the potential benefit justifies the potential risk to the foetus or nursing infant.

Reported local adverse reactions associated with corticosteroids are burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, maceration of the skin, secondary infection, skin atrophy, striae and miliria. Salicylic acid preparations may cause dermatitis.

Not known.

If symptoms persist please consult a doctor or pharmacist.
This preparation is for the treatment of current condition only.
Do not allow use by any other person and dispose of unused material when the treatment is complete.

Keep container well closed. Protect from strong light. Store below 30°C. For external use only.
Shelf-life: 3 years.

Topical Corticosteroids

D07BC01 - betamethasone and antiseptics ; Belongs to the class of potent (group III) corticosteroids, in combination with antiseptics. Used in the treatment of dermatological diseases.

POM