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Pharmacology: Pharmacodynamics: Betamethasone dipropionate is a topically active fluorinated corticosteroid which has anti-inflammatory, anti-pruritic and vasoconstrictive actions. Salicylic acid has keratolytic properties, as well as bacteriostatic and fungicidal actions.
Pharmacokinetics: When administered topically, particularly under occlusive dressing or when the skin is broken, sufficient corticosteroid may be absorbed to give systemic effects. Corticosteroids are extensively bound to plasma proteins. Only unbound corticosteroid has pharmacological effects or is metabolized. They are metabolized mainly in the liver, also in the kidney and are excreted in the urine. When salicylic acid is administered topically to large areas of the body, it may cause symptoms of acute systemic salicylate poisoning.
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