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Effects of Daptomycin for injection on Other Drugs: Daptomycin for injection was studied in adult human drug-drug interaction studies with aztreonam, tobramycin, warfarin, simvastatin, and probenecid. Daptomycin had no effect on the pharmacokinetics of warfarin or probenecid, nor did these drugs alter the pharmacokinetics of daptomycin. The pharmacokinetics of daptomycin were not significantly altered by aztreonam.
Experience with the concomitant administration of Daptomycin for injection and warfarin is limited. Studies of Daptomycin for injection with anticoagulants other than warfarin have not been conducted. Monitor anticoagulant activity in patients receiving Daptomycin for injection and warfarin for the first several days after therapy with Daptomycin for injection is initiated.
Experience with the coadministration of HMG-CoA reductase inhibitors and Daptomycin for injection in patients is limited; therefore, consider suspending use of HMG-CoA reductase inhibitors temporarily in patients receiving Daptomycin for injection.
Although small changes in the pharmacokinetics of daptomycin and tobramycin were observed during coadministration by IV infusion over a 30-minute period using a Daptomycin for injection dose of 2 mg/kg, the changes were not statistically significant. The interaction between daptomycin and tobramycin with a clinical dose of Daptomycin for injection is unknown. Caution is warranted when Daptomycin for injection is coadministered with tobramycin.
