Bedapt Daptomycin Dosage/Direction for Use

General: Daptomycin for injection is given by intravenous (IV) administration.
Daptomycin for injection is a sterile product contained in a single-dose vial.
Adults: Complicated Skin and Skin Structure Infections: Daptomycin for injection 4 mg/kg is administered to adult patients intravenously in 0.9% sodium chloride for injection once every 24 hours for 7 to 14 days, either by injection over a 2-minute period or by infusion over a 30-minute period. Do not dose Daptomycin for injection more frequently than once a day, and measure creatine phosphokinase (CPK) levels at baseline and at regular intervals (at least weekly). [See Instructions for Use: Preparation of Daptomycin for injection for Administration under Cautions for Usage.]
Staphylococcus aureus Bloodstream Infections (Bacteremia): Daptomycin for injection 6 mg/kg is administered to adult patients intravenously in 0.9% sodium chloride for injection once every 24 hours for 2 to 6 weeks, either by injection over a 2-minute period or by infusion over a 30-minute period. Duration of treatment is based on the treating physician's working diagnosis. Do not dose Daptomycin for injection more frequently than once a day, and measure CPK levels at baseline and at regular intervals (at least weekly). [See Instructions for Use: Preparation of Daptomycin for injection for Administration under Cautions for Usage.]
Pediatric Patients (1 to 17 Years of Age): Complicated Skin and Skin Structure Infections: The recommended dosage regimens based on age for pediatric patients with cSSSI are shown in Table 4. Daptomycin for injection should be administered intravenously in 0.9% sodium chloride for injection once every 24 hours for up to 14 days.
Unlike in adults, Daptomycin for injection should not be administered by injection over a two (2) minute period in pediatric patients. (See Table 4.)

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Staphylococcus aureus Bloodstream Infections (Bacteremia): The recommended dosage regimens based on age for pediatric patients with S. aureus bloodstream infections (bacteremia) are shown in Table 5. Daptomycin for injection should be administered intravenously in 0.9% sodium chloride for injection once every 24 hours for up to 42 days. (See Table 5.)

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Renal Impairment: Daptomycin is eliminated primarily by the kidneys; therefore, an adjustment of Daptomycin for injection dosage interval is recommended for adult patients with creatinine clearance (CL_CR) <30 mL/min, including patients receiving hemodialysis or continuous ambulatory peritoneal dialysis (CAPD). The recommended dosing regimen for these adult patients is 4 mg/kg (cSSSI) or 6 mg/kg (S. aureus bloodstream infections) once every 48 hours. When possible, administer Daptomycin for injection following the completion of hemodialysis on hemodialysis days. In adult patients with renal impairment, monitor both renal function and CPK more frequently than once weekly.
No dosage interval adjustment is required for adult patients with CL_CR ≥30 mL/min.
Due to limited clinical experience, Daptomycin for injection should only be used in adult patients with any degree of renal impairment (creatinine clearance <80 mL/min) when it is considered that the expected clinical benefit outweighs the potential risk. The response to treatment and renal function should be closely monitored in all adult patients with some degree of renal impairment. (See Table 6.)

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The dosage regimen for Daptomycin for injection in pediatric patients with renal impairment has not been established.