Aquipta Dosage/Direction for Use

Recommended dosage: The recommended dosage for AQUIPTA is 60 mg taken orally once daily with or without food.
There is no data that the 60 mg tablet can be divided into equal halves.
Missed dose: A missed dose should be taken right away. If it is almost time for the next dose, patients should be instructed to skip the missed dose and take the next dose as scheduled.
Dose modification: Dosing modifications for concomitant use of specific drugs (see Interactions) and for patients with renal impairment are provided in Table 5. (See Table 5.)

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Dosing in special populations: Pediatrics: Safety and effectiveness of AQUIPTA in pediatric patients have not been established.
Geriatric: Population pharmacokinetic modeling suggests no clinically significant pharmacokinetic differences between elderly and younger subjects. No dose adjustment of AQUIPTA is needed in elderly patients.
Renal impairment: For patients with severe renal impairment and ESRD, see dose adjustment in Table 5. No dose adjustment is recommended for patients with mild or moderate renal impairment.
For patients with ESRD undergoing intermittent dialysis, AQUIPTA should preferably be taken after dialysis.
Hepatic impairment: Avoid use of AQUIPTA in patients with severe hepatic impairment (Child-Pugh Class C) (see Pharmacology under Actions). No dose adjustment is recommended for patients with mild (Child-Pugh Class A) or moderate (Child-Pugh Class B) hepatic impairment.