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Pharmacology: Pharmacodynamics: Azithromycin is a 15-membered ring azalide antibiotic. Azithromycin interferes with ribosome function in susceptible bacteria by inhibiting the translocation of peptides, achieved through specific competitive binding to its target site on the 50S ribosomal subunit.
Pharmacokinetics: After oral administration, azithromycin rapidly absorbed and widely distributed throughout the body. It is extensively distributed to the tissues and peak plasma concentrations are achieved in 2 to 3 hours after oral administration. The average half-life of azithromycin is 68 hours. The serum protein binding of azithromycin is variable, ranging from 12% to 50%, depending on concentration. Azithromycin is excreted in bile as unchanged drug and metabolites. Approximately 6% of an oral dose is excreted in the urine.
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