Zithrocare 200/Zithrocare 500 Drug Interactions

Zithrocare 200: Nelfinavir: Co-administration of nelfinavir at steady-state with a single oral dose of azithromycin resulted in increased azithromycin serum concentration. Although dose adjustment of azithromycin is not recommended then administered in combination with nelfinavir, close monitoring for known adverse reactions of azithromycin, such as liver enzyme abnormalities and hearing impairment, is warranted.
Warfarin: Spontaneous post-marketing reports suggests that concomitant administration of azithromycin may potentiate the effects of oral anticoagulants such as warfarin, although the prothrombin time was not affected in the dedicated drug interaction study with azithromycin and warfarin. Prothrombin time should be carefully monitored while patients are receiving azithromycin and oral anticoagulants concomitantly.
Zithrocare 500: Caution is advised while using azithromycin in conjunction with drugs like carbamazepine, corticosteroids, cyclosporine, digoxin, ergot alkaloids, theophylline and warfarin.
Azithromycin should be taken at least one hour before or two hours after administration of food and antacid preparations.