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Dosage adjustment may be required in renal impairment but recommendations vary.
Only limited clinical data are also available for patients with recent myocardial infarction, uncompensated congestive heart failure and uncontrolled hypertension, use of memantine in these patients should be closely monitored. Seizures have occurred rarely and caution is recommended in patients at risk of convulsions.
Conditions that increase urinary pH eg, drastic changes in diet, renal tubular acidosis or severe infections of the urinary tract, may decrease elimination of memantine resulting in increased plasma levels; patient monitoring is recommended in such cases.
Pediatric Use: There are no adequate and well-controlled trials documenting the safety and efficacy of memantine in any illness occurring in children.
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