Zimerz Dosage/Direction for Use

Memantine is a derivative of amantadine and is likewise antagonist of N-methyl-D-aspartate receptors. It is given by mouth as the hydrochloride. It can be taken with or without food.
The initial dose of memantine hydrochloride is 5 mg daily in the morning for the first week; this should be increased in weekly increments of 5 mg to a maximum dose of 20 mg daily. Dose of 10 mg daily and over should be taken in 2 divided doses. Reduced doses are recommended in patients with renal impairment. Clinical benefit should be reassessed on a regular basis.
Administration in renal impairment: In UK no dose adjustment is needed when memantine hydrochloride is given to patients with mild renal impairment. However, in those with moderate impairment (creatinine clearance 40 to 60 mL/minute per 1.73 m²) the maximum dose should be reduced to 10mg daily, no data are available for patients with severe impairment.
While in US, no dose reduction is required in those with mild to moderate impairment; a target dose of 10 mg is recommended in patients with severe impairment (creatinine clearance 5 to 29 mL /minute).