Dose may be given by deep IM inj or IV by slow inj over 3-5 min or by infusion over 20-60 min.
Adult Usual dose: 2-6 g daily in 2-4 divided doses.
Severe infections Up to 12 g IV daily in 6 divided doses.
Pseudomonal infections >6 g daily.
Gonorrhoea 500 mg or 1 g as a single dose.
Gonococcal urethritis/cervicitis in male & female, & rectal gonorrhea in female 500 mg IM once daily.
Rectal gonorrhea in male 1 g IM once daily.
Uncomplicated infections 1 g IM/IV bid.
Moderate to severe infections 1-2 g IM/IV every 8 hr.
Infections commonly needing antibiotics in higher dosage (eg, septicemia) 2 g IV every 6-8 hr.
Life-threatening infections 2 g IV every 4 hr. Add appropriate anti-chlamydial coverage if
C. trachomatis is suspected.
Surgical infection prophylaxis 1 g 30-90 min before surgery.
Caesarean section 1 g IV as soon as the umbilical cord is clamped & 2 further doses IM/IV 6-12 hr later.
Childn 100-150 mg/kg daily in 2-4 divided doses.
Severe infections 200 mg/kg daily.
Childn & infant (1 mth-12 yr) ≥50 kg Usual adult dose, not exceeding 12 g,
<50 kg 50-180 mg/kg IM/IV, divided into 4-6 equal doses.
Neonate 50 mg/kg daily in 2-4 divided doses.
Severe infections 150-200 mg daily,
1-4 wk 50 mg/kg IV every 8 hr,
0-1 wk 50 mg/kg IV every 12 hr.
Renal impairment Initially 1 g, halving the dose while maintaining usual frequency of dose has been suggested.
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