Xabitor 2.5/Xabitor 5 Overdosage

There is no antidote to apixaban. Overdose of apixaban may result in a higher risk of bleeding. In the event of hemorrhagic complications, treatment must be discontinued and the source of bleeding investigated. The initiation of appropriate treatment, eg., surgical hemostasis or the transfusion of fresh frozen plasma should be considered.
In controlled clinical trials, orally-administered apixaban in healthy subjects at doses up to 50 mg daily for 3 to 7 days (25 mg twice daily (bid) for 7 days or 50 mg once daily (od) for 3 days) had no clinically relevant adverse effects.
Administration of activated charcoal 2 and 6 hours after ingestion of a 20-mg dose of Apixaban reduced mean Apixaban AUC by 50% and 27%, respectively, and had no impact on Cmax. Mean half-life of Apixaban decreased from 13.4 hours when Apixaban was administered alone to 5.3 hours and 4.9 hours, respectively, when activated charcoal was administered 2 and 6 hours after Apixaban. Thus, administration of activated charcoal may be useful in the management of Apixaban overdose or accidental ingestion.