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Pregnancy: Folic acid deficiency during pregnancy may lead to the appearance of foetal malformations. Imbalance in folate requiring trophoblast cells may also lead to detachment of the placenta.
Very high doses of folic acid have been shown to cause foetal abnormalities in rats; however, harmful effects in the human foetus, mother or the pregnancy have not been reported following ingestion of folic acid.
Breastfeeding: Folic acid is excreted in breast milk.
No adverse effects have been observed in breast-fed infants whose mothers were receiving folic acid.
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