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This combination is contraindicated in patients who are hypersensitive to any component of this product.
Patients allergic to angiotensin receptor blocker or dihydropyridine Calcium channel antagonist.
Patients with history of angioedema.
Hypersensitivity to the active substance or to any of the excipients.
Losartan is contraindicated in the 2nd and 3rd trimester of pregnancy. Severe hepatic impairment. Losartan should not be administered with aliskiren in patients with diabetes mellitus or renal impairment (GFR < 60 mL/min/1.73 m2).
Amlodipine is contraindicated in patients with: hypersensitivity to dihydropyridine derivatives, amlodipine or any of the excipients; severe hypotension; shock (including cardiogenic shock); obstruction of the outflow tract of the left ventricle (e.g. high grade aortic stenosis); haemodynamically unstable heart failure after acute myocardial infarction.
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