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Pharmacology: Zoledronic acid; belongs to the class of bisphosphonates. Used in the treatment of bone diseases.
General: Principal pharmacological action of Zoledronic acid is bone resorption inhibition. Although it is not completely known the mechanism of action for the antiresorptive activity, it is believed that several factors contribute to this action. Zoledronic acid in vitro inhibits the activity of osteoclasts and induces their apoptosis. Zoledronic acid also blocks the osteoclastic.
