Vexonib-4 Dosage/Direction for Use

Zoledronic acid is given as an intravenous infusion over not less than 15 minutes. It is used or hypercalcemia of malignancy, in a single dose of 4 mg, diluted with 100 mL of sodium chloride 0.9% or glucose 5%. The treatment may be repeated if necessary after at least 7 days, at a dose of 4 mg. Individual doses should not exceed 4 mg, as there is an increased risk of adverse renal effects, including renal failure.
Zoledronic acid is given for the prevention of skeletal events in patients with advanced bone malignancies at a dose of 4 mg, diluted as above, every 3 to 4 weeks. For the treatment of Paget's disease of bone, zoledronic acid is given as a single intravenous infusion of 5 mg.
Zoledronic acid is also used for the treatment of osteoporosis in postmenopausal women; the recommended dose is a single.