Vatacil Special Precautions

Ampicillin should be discontinued if a skin rash occurs. It should preferably not be given to patients with infectious mononucleosis since they are especially susceptible to ampicillin-induced skin rashes; patients with lymphatic leukemia or HIV infection may also be at increased risk to developing skin rashes.
Use in Pregnancy: Anaphylaxis is a fairly uncommon event in pregnancy that can have serious implications for both mother and fetus. Several central nervous system damage in the preterm fetus and death in infancy have been attributed to maternal hypotensive anaphylaxis whereas at term the fetus has been regarded as protected. Several fatal complications after intravenous application of ampicillin to a woman at term have been reported. This case demonstrates that the fetus near term may not be protected against severe damaged caused by anaphylaxis. Therefore drugs with the potential to produce anaphylactic reactions should be given with caution in pregnancies at term. Intensive fetal monitoring in anaphylactic reaction is necessary to allow rapid delivery of the infant.