Ampicillin may decrease the efficacy of estrogen-containing oral contraceptives. It may also affect the absorption of other drugs due to its effect on the gastrointestinal flora. The possibility of a prolonged bleeding time following oral treatment with a broad spectrum antibiotic like ampicillin should be borne in mind in patients receiving coagulants. There may be antagonism between ampicillin, a bactericidal agent and bacteriostatic agents such as Chloramphenicol, Incompatibility in vitro with other drugs may occur. An increased frequency of skin rashes has been reported in patients receiving ampicillin with allopurinol, compared with those receiving the antibiotic alone.
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