Vasalat Drug Interactions

The following drug interactions and/or related problems have been selected on the basis of their potential clinical significance.
Note: Combinations containing any of the following medications, depending on the amount present, may also interact with Vasalat.
Inhalational Anesthetics Hydrocarbon: Concurrent use with amlodipine may produce additive hypotension although calcium-channel blocking agents may be useful to prevent supraventricular tachycardias, hypertension or coronary spasm during surgery. Caution is recommended during use.
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) Especially Indomethacin: NSAIDs may reduce the antihypertensive effects of amlodipine by inhibiting renal prostaglandin synthesis and/or causing sodium and fluid retention.
β-Adrenergic Blocking Agents: Although reports of adverse effects resulting from concurrent use of amlodipine with the β-adrenergic blocking agents are lacking, caution is recommended given the similarity of amlodipine to nifedipine; concurrent use of nifedipine with the β-adrenergic blocking agents, although usually well-tolerated, may produce excessive hypotension and, in rare cases, may increase the possibility of congestive heart failure.
Estrogens: Estrogen-induced fluid retention may tend to increase blood pressure, the patient should be carefully monitored to confirm that the desired effect is being obtained.
Highly protein bound medications eg, anticoagulants, coumarin- and indandione-derivatives; anticonvulsants, hydantoin; NSAIDs; quinine; salicylates; sulfinpyrazone. Caution is advised when these medications are use concurrently with amlodipine since amlodipine is highly protein bound; changes in serum concentrations of the free, unbound medications may occur.
Hypotension-Producing Medications: Antihypertensive effects may be potentiated when amlodipine is used concurrently with hypotension-producing medications; although some antihypertensive and/or diuretic combinations are used concurrently, dosage adjustments may be necessary.
Lithium: Concurrent use with amlodipine potentially may result in neurotoxicity in the form of nausea, vomiting, diarrhea, ataxia, tremors and/or tinnitus; caution is recommended.
Sympathomimetics: Concurrent use may reduce antihypertensive effects of amlodipine; the patient should be carefully monitored to confirm that the desired effect is being obtained.