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Bile Acid Sequestering Agents: Bile acid sequestering agents such as cholestyramine and colestipol may interfere with the action of Ursodeoxycholic acid tablet by reducing its absorption.
Aluminum-Based Antacids: Aluminum-based antacids have been shown to adsorb bile acids in vitro and may be expected to interfere with Ursodeoxycholic acid tablet in the same manner as the bile acid sequestering agents.
Drugs Affecting Lipid Metabolism: Estrogens, oral contraceptives, and clofibrate (and perhaps other lipid-lowering drugs) increase hepatic cholesterol secretion and encourage cholesterol gallstone formation and hence may counteract the effectiveness of Ursodeoxycholic acid tablet.
