Sign Out
Reports of inadvertent overdose and observations from a high-dose tolerability study in healthy volunteers showed that, in adults, single doses in the range of approximately 4 g to 7 g of mesna can cause symptoms such as nausea, vomiting, abdominal pain/colic, diarrhea, headache, fatigue, limb and joint pains, rash, flushing, hypotension, bradycardia, tachycardia, paresthesia, fever, and bronchospasm.
A markedly increased rate of nausea, vomiting and diarrhea has also been found in oxazaphosphorine-treated patients receiving ≥80 mg mesna per kg per day intravenously compared with patients receiving lower doses or hydration treatment only.
A specific antidote to mesna is not known.
Continue with Google